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Title 

Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa

Authors 

G H XuYoung-hee KimSeung-Wook ChiSoo-Jin ChooIn Ja RyooJong Seog AhnIck Dong Yoo

Publisher 

Elsevier

Issue Date 

2010

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 20, no. 2, pp. 513-515

Keywords 

Hedyotis diffusaHuman neutrophil elastaseIridoid glycosides

Abstract 

Five iridoid glycosides were isolated from the MeOH extract of Hedyotis diffusa, and their structures were elucidated as E-6-O-p-methoxycinnamoyl scandoside methyl ester (1), Z-6-O-p-methoxycinnamoyl scandoside methyl ester (2), E-6-O-p-feruloyl scandoside methyl ester (3), E-6-O-p-coumaroyl scandoside methyl ester (4), and Z-6-O-p-coumaroyl scandoside methyl ester (5) by interpretation of their spectroscopic data. All the isolated compounds were evaluated for human neutrophil elastase inhibitory effect, and compound 1 showed potent activity with an IC50 value of 18.0 μM. The molecular docking simulation suggested a structural model for the inhibition of human neutrophil elastase by compound 1.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2009.11.109

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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