상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Tristetraprolin regulates the stability of HIF-1α mRNA during prolonged hypoxia

Authors 

Tae-Woo KimS YimByeong Jung ChoeYeo-Jin JangJ J LeeBo Hwa SohnHyang Sook YooYoung Il YeomKyung Chan Park

Publisher 

Elsevier

Issue Date 

2010

Citation 

Biochemical and Biophysical Research Communications, vol. 391, no. 1, pp. 963-968

Keywords 

AU-rich elementHIF-1αTristetraprolinTTPUTR

Abstract 

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor involved in the cancer cell adaptation to hypoxia, a leading cause of tumor malignancy. Thus, control of HIF-1α expression may assist in treatment of cancer. The expression of HIF-1α is finely regulated via alterations in not only HIF-1α protein stability but also mRNA stability. However, the molecular mechanisms of regulation of HIF-1α mRNA stability have not yet been fully elucidated. Here, we show that tristetraprolin (TTP) protein, of which the mRNA expression level is downregulated in most of hepatocellular carcinoma tissues, bound directly to the 3′-UTR of HIF-1α mRNA containing eight putative TTP-binding motifs, AU-rich elements (AUUUA), to downregulate stability. Furthermore, TTP expression was induced in hypoxic cells, and overexpression of TTP repressed the hypoxic induction of HIF-1α protein. Taken together, these data suggest that TTP is a modulator of HIF-1α expression during hypoxia and may play a physiological role in regulation between cellular adaptation and apoptosis in prolonged hypoxia. In addition, cancer cells may benefit from the downregulation of TTP, which subsequently increases HIF-1α expression and assists with the adaptation of cancer cells to hypoxia.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2009.11.174

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)