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Title 

Anti-inflammatory and anti-asthmatic effects of Viola mandshurica W. Becker (VM) ethanolic (EtOH) extract on airway inflammation in a mouse model of allergic asthma

Authors 

M Y LeeJi Eun YukOk-Kyoung KwonHui Seong KimSei Ryang OhHyeong Kyu LeeKyung Seop Ahn

Publisher 

Elsevier

Issue Date 

2010

Citation 

Journal of Ethnopharmacology, vol. 127, no. 1, pp. 159-164

Keywords 

Airway hyperresponsivenessAsthmaCytokineEosinophiliaViola mandshurica W. Becker

Abstract 

Aim of the study: We investigated the efficacy of Viola mandshurica W. Becker (VM) ethanolic (EtOH) extract in the treatment of bronchial asthma in an ovalbumin (OVA)-induced asthmatic BALB/c mouse model. Materials and methods: Female BALB/c mice were sensitized with intraperitoneal (i.p.) ovalbumin (OVA) on days 0 and 14, and were next given intranasal OVA on days 28-30. Randomized treatment groups of sensitized mice received VM EtOH extract, dexamethasone, or placebo, orally, from days 28 to 30. Results: VM EtOH extract significantly inhibited increases in total immunoglobulin E (IgE) and cytokines IL-4 and IL-13 levels in serum and bronchoalveolar lavage fluid (BALF), and also effectively suppressed airway hyperresponsiveness (AHR), eosinophilia, and mucus hypersecretion, in mice with OVA-induced asthma. Conclusions: The results suggest that VM EtOH extract and allied extracts could be useful herbal medicines for asthma treatment, and that VM may also be a valuable lead material for anti-asthma drug development.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/j.jep.2009.09.033

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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