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Title 

Rubus coreanus extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 3A4

Authors 

Young Ik LeeK E WhangJ S ChoB M AhnS B LeeM S DongT H Kim

Publisher 

Korean Society of Applied Pharmacology

Issue Date 

2009

Citation 

Biomolecules & Therapeutics, vol. 17, no. 4, pp. 455-460

Keywords 

AcetaminophenAnti-oxidant effectCytochrome p450Ellagic acidHepatoprotective effectRubus coreanus

Abstract 

Foods of plant origin, especially fruits and vegetables, have attracted attention because of their potential benefits to human health. In this report, Rubi Fructus (RF), the dried unripe fruit of Rubus coreanus Miq (Rosaceae) and ellagic acid (EA) purified from RF were used to test their potential hepatoprotective effect against acetaminophen (AAP)-induced hepatotoxicity in rats. RF extract (RFext) and EA reduced the elevated levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) in serum and the content of lipid peroxide in liver by AAP administration, while the increment of the cellular glutathione (GSH) content and the induction of glutathione S-transferase (GST) and glutathione peroxidase (GSH-PX) which were decreased by AAP administration. RFext and EA from RFext did not affect the two major form of cytochrome P450s, cytochrome P450 2E1 (CYP2E1) and cytochrome P450 1A2 (CYP1A2), but down-regulated the cytochrome P450 3A4 (CYP3A4) related to the conversion of AAP to N-acetyl-P-benzoquinone imine (NAPQI). These results suggest that RFext and EA from RF exhibit a hepatoprotective effect not only by increasing antioxidant activities but also by down-regulating CYP3A4 in the AAP-intoxicated rat.

ISSN 

1976-9148

Link 

http://dx.doi.org/10.4062/biomolther.2009.17.4.455

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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