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Title 

Drosophila G9a is implicated in germ cell development

Authors 

Kyu-Sun LeeJ YoonJung Sun ParkYong-Kook Kang

Publisher 

Wiley-Blackwell

Issue Date 

2010

Citation 

Insect Molecular Biology, vol. 19, no. 1, pp. 131-139

Keywords 

DG9aDrosophilaFusomeGermline cellHistone methylationOogenesisSpectrosome

Abstract 

In Drosophila ovaries, germline stem cells (GSCs) divide asymmetrically in the germaria to produce daughter GSCs and cystoblasts. Single cystoblasts differentiate to form germline cysts with 16 germline cells, all of which are connected by the fusome, a vesiculated structure critical for oocyte specification. We here show that histone H3K9 methyltransferase dg9a is associated with spectrosome/fusome formation in the germarium; dG9a 13414 mutant ovaries have disorganized spectrosome/fusome in about half the germaria, with reduced levels of hu-li tai shao and α-SPECTRIN proteins. We found that the amount of germline cells within cysts was reduced and that oocyte determination often failed in egg chambers of the dG9a 13414 mutant ovaries. These results suggest that a mutation in dG9a gene gives rise to anomalous spectrosome/fusome structures, which in turn lead to faulty germ-cell development in Drosophila ovaries.

ISSN 

0962-1075

Link 

http://dx.doi.org/10.1111/j.1365-2583.2009.00955.x

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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