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Title 

Inhibition of neuraminidase activity by polyphenol compounds isoalated from the roots of Glycyrrhiza uralensis

 

감초뿌리로부터 뉴라미니데이즈 저해제인 폴리페놀 화합물 개발

Authors 

Young Bae RyuJang Hun KimSu-Jin ParkJong Sun ChangMun Chual RhoK H BaeK H ParkWoo Song Lee

Publisher 

Elsevier

Issue Date 

2010

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 20, no. 3, pp. 971-974

Keywords 

Anti-influenzaCoumestanGlycyrrhiza uralensisNeuraminidase

Abstract 

We isolated 18 polyphenols with neuraminidase inhibitory activity from methanol extracts of the roots of Glycyrrhiza uralensis. These polyphenols consisted of four chalcones (1-4), nine flavonoids (5-13), four coumarins (14-17), and one phenylbenzofuran (18). When we tested the effects of these individual compounds and analogs thereof on neuraminidase activation, we found that isoliquiritigenin (1, IC50 = 9.0 μM) and glycyrol (14, IC50 = 3.1 μM) had strong inhibitory activity. Structure-activity analysis showed that the furan rings of the polyphenols were essential for neuraminidase inhibitory activity, and that this activity was enhanced by the apioside group on the chalcone and flavanone backbone. In addition, the presence of a five-membered ring between C-4 and C-2′ in coumestan was critical for neuraminidase inhibition. All neuraminidase inhibitors screened were found to be reversible noncompetitive inhibitors.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2009.12.106

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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