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Title 

Neuroprotective effects of Triticum aestivum L. against β-Amyloid-induced cell death and memory impairments

Authors 

J H JangC Y KimS H LimC H YangK S SongH S HanHyeong Kyu LeeJ Lee

Publisher 

Wiley-Blackwell

Issue Date 

2010

Citation 

Phytotherapy Research, vol. 24, no. 1, pp. 76-84

Keywords 

β-amyloidApoptosisMemoryOxidative stressScopolamineTriticum aestivum L.

Abstract 

β-Amyloid (Aβ) is a key component of senile plaques, neuropathological hallmarks of Alzheimer's disease (AD) and has been reported to induce cell death via oxidative stress. This study investigated the protective effects of Triticum aestivum L. (TAL) on Aβ-induced apoptosis in SH-SY5Y cells and cognitive dysfunctions in Sprague-Dawley (SD) rats. Cells treated with Aβ exhibited decreased viability and apoptotic features, such as DNA fragmentation, alterations in mitochondria and an increased Bax/Bcl-2 ratio, which were attenuated by TAL extract (TALE) pretreatment. To elucidate the neuroprotective mechanisms of TALE, the study examined Aβ-induced oxidative stress and cellular defense. TALE pretreatment suppressed Aβ-increased intracellular accumulation of reactive oxygen species (ROS) via up-regulation of glutathione, an essential endogenous antioxidant. To further verify the effect of TALE on memory impairments, Aβ or scopolamine was injected in SD rats and a water maze task conducted as a spatial memory test. Aβ or scopolamine treatment increased the time taken to find the platform during training trials, which was decreased by TALE pretreatment. Furthermore, one of the active components of TALE, total dietary fiber also effectively inhibited Aβ-induced cytotoxicity and scopolamine-caused memory deficits. These results suggest that TALE may have preventive and/or therapeutic potential in the management of AD.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.2871

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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