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Title 

Antiviral and anticancer activities of 13(E)-labd-13-ene-8α,15-diol isolated from Brachyglottis monroi

Authors 

Hwa-Jung ChoiJ H SongDur Han KwonS H Baek

Publisher 

Wiley-Blackwell

Issue Date 

2010

Citation 

Phytotherapy Research, vol. 24, no. 2, pp. 169-174

Keywords 

13(E)-labd-13-ene-8α,15-diolAnticancer activityAntiviral activityBrachyglottis monroiHuman rhinovirus

Abstract 

The antiviral activity of 13(E)-labd-13-ene-8α,15-diol (1), isolated from Brachyglottis monroi, was examined against human rhinovirus 2 (HRV2) and 3 (HRV3), and the anticancer activity on human cancer cells (A549 and Hep2). Compound (1) showed strong anti-HRV2 and HRV3 activity with a 50% inhibitory concentration (IC50) of 2.68 and 0.87 μg/mL, respectively, and a 50% cytotoxicity concentration (CC50) of 59.45 μg/mL. Ribavirin only showed anti-HRV3 activity with an IC50 of 30.48 mg/mL and a CC50 > 100 μg/mL. The addition of compound (1) to HRV-infected HeLa cells directly reduced the formation of visible cytopathic effect (CPE) and it directly interacted with HRV particles. Furthermore, A549 and Hep2 cells incubated with 32 μg/mL of compound (1) for 48 h exhibited antilung and antilaryngeal cancer activities, with a viability of less than 50%. These results suggest that compound (1) may be used as a potential antiviral and anticancer agent.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.2875

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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