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Title 

Glabridin inhibits lipopolysaccharide-induced activation of a microglial cell line, BV-2, by blocking NF-κB and AP-1

Authors 

S H ParkJong Soon KangY D YoonKiho LeeK J KimKi Hoon LeeChang Woo LeeE Y MoonS B HanB H KimHwan Mook KimSong Kyu Park

Publisher 

Wiley-Blackwell

Issue Date 

2010

Citation 

Phytotherapy Research, vol. 24, no. S1, pp. S29-S34

Keywords 

GlabridinInterleukin-1βLipopolysaccharideMicrogliaNitric oxideTumor necrosis factor-α

Abstract 

Glabridin, a flavonoid present in licorice root, is known to have antiinflammatory and cardiovascular protective activities. The present study reports an inhibitory effect of glabridin on microglial activation. Glabridin dose-dependently attenuated lipopolysaccharide (LPS)-induced production of inflammatory mediators, including nitric oxide, tumor necrosis factor-α and interleukin-1β, in BV-2 cells, a murine microglia cell line. Moreover, mRNA expression of these inflammatory mediators was also suppressed by glabridin in LPS-stimulated BV-2 cells. Further study demonstrated that glabridin inhibited LPS-induced DNA binding activity of NF-κB and AP-1 in BV-2 cells. Collectively, the results presented in this report demonstrate that glabridin inhibits the production of inflammatory mediators in BV-2 cells and this is mediated, at least in part, by blocking NF-κB and AP-1 activation. The results suggest that glabridin might be a potential therapeutic agent for the treatment of neuroinflammatory and neurodegenerative diseases.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.2872

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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