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Title 

Isolation and identification of FR198248, a hydroxylated 1,4-dihydroisobenzofuran, from Aspergillus flavipes F543 as an inhibitor of peptide deformylase

 

Aspergillus flavipes균주로 부터 PDF 저해제 FR198248의 분리 및 동정

Authors 

Yun-Ju KwonC J ZhengWon Gon Kim

Publisher 

Japan Society for Bioscience, Biotechnology and Agrochemistry

Issue Date 

2010

Citation 

Bioscience Biotechnology and Biochemistry, vol. 74, no. 2, pp. 390-393

Keywords 

1,3-dihydroisobenzofuranAntibacterialAspergillus flavipesPeptide deformylaseStaphylococcus aureus

Abstract 

Two highly hydroxylated 1,3-dihydroisobenzofurans, FR198248 (1) and FR202306 (2), were isolated as peptide deformylase (PDF) inhibitors from Aspergillus flavipes. Compounds 1 and 2 inhibited Staphylococus aureus PDF with IC50 values of 3.6 and 2.5 μM, respectively, and also showed antibacterial activity with an MIC value of 25 μg/ml. In contrast, 6-O-methyl derivative 3 of compound 2 was inactive against both PDF and S. aureus.

ISSN 

0916-8451

Link 

http://dx.doi.org/10.1271/bbb.90565

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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