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Title 

A lipid-soluble red ginseng extract inhibits the growth of human lung tumor xenografts in nude mice

Authors 

S D LeeSong Kyu ParkE S LeeHwan Mook KimChang Woo LeeKiho LeeKi Hoon LeeMoorim KangK S LeeJ LeeW I HwangD C Kim

Publisher 

Mary Ann Liebert

Issue Date 

2010

Citation 

Journal of Medicinal Food, vol. 13, no. 1, pp. 1-5

Keywords 

Anticancer effectHuman tumor xenograftLipid-soluble ginseng extractOral administration

Abstract 

Lipid-soluble ginseng extract was prepared by n-hexane extraction of red ginseng. BALB/c-nu mice were inoculated with human lung cancer (NCI-H460) cells to establish a human tumor xenograft model in nude mice, and the lipid-soluble ginseng extract was orally administered. The tumor inhibitory rates of the lipid-soluble ginseng extract at doses of 0.1, 0.3, and 1.0g/kg/day were 18.9% (P<.05), 60.0% (P<.001), and 67.5% (P<.001), respectively. The oral administration of the lipid-soluble extract of red ginseng showed a potent anticancer effect in nude mice bearing human lung cancer cells in a dose-dependent manner without any apparent toxicity. This lipid-soluble ginseng extract is a potential nontoxic anticancer supplement for the prevention and intervention of lung tumor growth through an oral administration route.

ISSN 

1096-620X

Link 

http://dx.doi.org/10.1089/jmf.2009.1142

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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