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Title 

Tristetraprolin regulates expressin of VEGF and tumorigenesis in human colon cancer

 

인간 대장암에서의 트리스테트라프롤린에 의한 VEGF 발현 및 암화의 조절

Authors 

H H LeeY J SonW H LeeYoung Woo ParkS W ChaeW J ChoY M KimH J ChoiD H ChoiS W JungY J MinS E ParkB J LeeH J ChaJ W Park

Publisher 

Wiley-Blackwell

Issue Date 

2010

Citation 

International Journal of Cancer, vol. 126, no. 8, pp. 1817-1827

Abstract 

Tristetraprolin (TTP) is an AU-rich element-binding protein that regulates mRNA stability. Here, we report that TTP suppress the growth of human colon cancer cells both in vivo and in vitro by regulating of the expression of vascular endothelial growth factor (VEGF). TTP protein expression in human colonic tissues was markedly decreased in colonic adenocarcinoma compared with in normal mucosa and adenoma. VEGF expression was higher in colonic adenocarcinoma than in normal mucosa and adenoma. Specific inhibition of TTP expression by RNA-interference increased the expression of VEGF in cultured human colon cancer cells, and TTP overexpression markedly decreased it. In addition, elevated expression of TTP decreased the expression level of luciferase linked to a 3' terminal AU-rich element (ARE) of VEGF mRNA. Colo320/TTP cells overexpressing TTP grew slowly in vitro and became tumors small in size when xenografted s.c into nude mice. These findings demonstrate that TTP acts as a negative regulator of VEGF gene expression in colon cancer cells, suggesting that it can be used as novel therapeutic agent to treat colon cancer.

ISSN 

0020-7136

Link 

http://dx.doi.org/10.1002/ijc.24847

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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