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Title 

Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone

 

설포닐아미노 칼콘의 미백활성

Authors 

W D SeoYoung Bae RyuM J Curtis-LongC W LeeH W RyuK C JangK H Park

Publisher 

Elsevier

Issue Date 

2010

Citation 

European Journal of Medicinal Chemistry, vol. 45, no. 5, pp. 2010-2017

Keywords 

ChalconeDepigmentationSulfonylamino chalconeTyrosinase

Abstract 

The 4′-(p-toluenesulfonylamino)-4-hydroxychalcone (TSAHC), which bears inhibitory chemotypes for both α-glucosidase and tyrosinase, was evaluated for tyrosinase activity and depigmenting ability relative to compounds designed to only target tyrosianse activity. TSAHC emerged to be a competitive reversible inhibitor of mushroom tyrosinase. More importantly, it was also able to return the melanin content of α-melanocyte stimulated by α-MSH to base levels unlike other inhibitors that only targeted tyrosinase. The Western blot for expression levels of proteins involved in melanogenesis showed that TSAHC significantly decreased three main tyrosinase related protein in melanin biosynthesis, tyrosinase, TRP-1 and TRP-2.

ISSN 

0223-5234

Link 

http://dx.doi.org/10.1016/j.ejmech.2010.01.049

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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