상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

2'-Hydroxycinnamaldehyde shows antitumor activity against oral cancer In vitro and In vivo in a rat tumor model

 

구강암에서의 CB-OH의 항암효과

Authors 

S A KimY K SungByoung-Mog KwonJ H YoonH LeeS G AhnS H Hong

Publisher 

International Institute of Anticancer Research (IIAR)

Issue Date 

2010

Citation 

Anticancer Research, vol. 30, no. 2, pp. 489-494

Keywords 

2'-HydroxycinnamaldehydeApoptosisCell cycleOral cancerTumor model

Abstract 

Background: 2′-Hydroxycinnamaldehyde (HCA) exerts antitumor activity against several human cancer cell lines. However, its antitumor activity in oral cancer has not been demonstrated. Materials and Methods: The antitumor activity of HCA was assessed in oral cancer cell lines and in a rat oral tumor model. Results: Cell cycle analysis confirmed that HCA showed anti-proliferative activity via cell cycle arrest at the G2/M-phase and increased the number of cells in the sub-G1 (apoptotic cells) phase in SCC-15 and HEp-2 oral cancer cells. Additionally, direct injection of HCA into an RK3E-ras-Fluc-induced tumor significantly inhibited growth of the tumor mass. Histological analysis showed that HCA decreased tumor cell proliferation and induced apoptosis in a rat tumor model. Conclusion: Taken together, these observations suggest the potential value of HCA as a candidate for the treatment of oral cancer.

ISSN 

0250-7005

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)