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Title 

Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor

Authors 

Y M LeeH LiJ HongH Y ChoKyung Sook BaeM A KimD K KimJ H Jung

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2010

Citation 

Archives of Pharmacal Research, vol. 33, no. 2, pp. 231-235

Keywords 

AnthraquinoneAntibacterial activityAspergillus versicolorCytotoxicityPolyketideXanthone

Abstract 

As part of an ongoing search for bioactive metabolites from the fungus Aspergillus versicolor derived from a marine sponge Petrosia sp., an aromatic polyketide derivative (1), two xanthones (2 and 3), and five anthraquinones (4-8) were isolated by bioactivity-guided fractionation. The gross structures were determined based on the NMR and MS spectroscopic data, and the absolute configurations were defined by comparison of optical rotation data with those of reported. Compounds 2, 4, 5, and 7 exhibited significant cytotoxicity against five human solid tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15) with IC50 values in the range of 0.41-4.61 μg/mL. Compounds 4 and 7 exhibited antibacterial activity against several clinically isolated Gram-positive strains with MIC values of 0.78-6.25 μg/mL.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-010-0207-4

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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