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Title 

TXNIP regulates germinal center generation by suppressing BCL-6 expression

Authors 

Y ShaoS Y KimD ShinMi-Sun KimHyun-Woo SuhZ H PiaoM JeongSuk Hyung LeeSuk Ran YoonB H LimW H KimJ K AhnIn Pyo Choi

Publisher 

Elsevier

Issue Date 

2010

Citation 

Immunology Letters, vol. 129, no. 2, pp. 78-84

Keywords 

B cellsBCL-6Germinal centerTXNIP

Abstract 

The detailed mechanism driving the germinal center (GC) reaction to B cell lymphomagenesis has not been clarified. Thioredoxin interacting protein (TXNIP), also known as vitamin D3 up-regulated protein 1 which is an important tumor repressor, is involved in stress responses, redox regulation, and cellular proliferation. Here, we report that TXNIP has a potential role in the formation of GC in peripheral lymphoid organs where B lymphocytes divide rapidly. First, we compared changes in GC from wild type mice and Txnip-/- mice. After immunization, Txnip-/- mice exhibited higher expression level of BCL-6 and larger percentage of GC B cells with the reduction in antibody production and plasma cell numbers. In addition, Txnip-/- spleens had a much larger population which expressed Ki-67, a marker of cell proliferation, in the red pulp border than WT spleens. Furthermore, the expression of BCL-6 was decreased in TXNIP overexpressing cells and elevated in TXNIP deficient cells. Taken together, we conclude that TXNIP may contribute to the formation of GCs after immunization. During this process, TXNIP suppresses BCL-6 expression.

ISSN 

0165-2478

Link 

http://dx.doi.org/10.1016/j.imlet.2010.02.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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