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Title 

Acanthoic acid, a diterpene in Acanthopanax koreanum, protects acetaminophen-induced hepatic toxicity in mice

Authors 

Y L WuY Z JiangX J JinL H LianJ Y PiaoY WanH R JinJung Joon LeeJ X Nan

Publisher 

Elsevier

Issue Date 

2010

Citation 

Phytomedicine, vol. 17, no. 6, pp. 475-479

Keywords 

Acanthoic acidAcanthopanax koreanumAcetaminophenAntioxidationHepatotoxicityHypoxia inducible factor-1α

Abstract 

The protective effect of a diterpenoid acanthoic acid (AA) isolated from Acanthopanax koreanum Nakai was investigated in acetaminophen (APAP)-induced hepatic toxicity. Drug-induced hepatotoxicity induced by an intraperitoneal (i.p.) injection of 300 mg/kg (sub-lethal dose) of APAP. Pretreatment with AA (50 and 100 mg/kg) orally 2 h before the APAP administration attenuated the APAP-induced acute increase in serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activites, replenished the depleted hepatic glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, decreased malondialdehyde (MDA) level and considerably reduced the histopathological alterations in a manner similar to silymarin (Sily). Immunohistochemical analyses also demonstrated that AA could reduce the appearance of necrosis regions as well as caspase-3 and hypoxia inducible factor-1α (HIF-1α) expression in liver tissue. Our results indicated that AA protected liver tissue from the oxidative stress elicites by APAP-induced liver damage and suggestes that the hepatic protection mechanism of AA would relate to antioxidation and hypoxia factor on APAP-induced hepatotoxicity.

ISSN 

0944-7113

Link 

http://dx.doi.org/10.1016/j.phymed.2009.07.011

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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