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Title 

Melanogenesis inhibitory effect of dehydroevodiamine isolated from fruits of Evodia rutaecarpa

 

Dehydroevodiamine의 미백활성

Authors 

L H LuoJeong Woo SeoD H NguyenE K KimS A KangD H KimChul Ho Kim

Publisher 

Korean Institute of Chemical Engineer

Issue Date 

2010

Citation 

Korean Journal of Chemical Engineering, vol. 27, no. 3, pp. 915-918

Abstract 

Dehydroevodiamine, an alkaloid, was isolated from the fruit of Evodia rutaecarpa and melanin production, and tyrosinase inhibition in B16F10 melanoma cells treated with the isolated dehydroevodiamine was investigated. The compound decreased melanin synthesis significantly without promoting cytotoxicity. The IC50 value of dehydroevodiamine for melanogenesis and cell viability were 59.8 μM and 90.0 μM, respectively. The L-dopa oxidase activity of mushroom tyrosinase was reduced after dehydroevodiamine treatment by about 22.4% at a concentration of 33.2 μM. However, there was no effect on cellular tyrosinase activity. These results indicate that the observed decrease in melanin content after treatment with dehydroevodiamine was attributed to the direct inhibition of tyrosinase activity, rather than the suppression of tyrosinase gene expression. Dehydroevodiamine may be a promising new agent for use in cosmeceutical application.

ISSN 

0256-1115

Link 

http://dx.doi.org/10.1007/s11814-010-0147-1

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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