상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Synthesis and In vitro cytotoxic activities of 2-Alkyl-2,3-dihydro-1H-2,6-diazacyclopenta(b)anthracene-5,10-diones

Authors 

J H KwakK NamgoongJ K JungS B HanJ ChoHwan Mook KimSong Kyu ParkKiho LeeJong Soon KangH Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2010

Citation 

Archives of Pharmacal Research, vol. 33, no. 5, pp. 663-667

Keywords 

Cytotoxic activityDiazacyclopenta[b]anthracene-5,10-diones

Abstract 

A series of 2-alkyl-2,3-dihydro-1H-2,6-diazacyclopenta[b]anthracene-5,10- diones (4a-f) was synthesized and their in vitro cytotoxic activities were evaluated against six human cancer cell lines (HCT15, SK-OV-3, SNB19, A549, MCF7 and MCF7/ADR). They all appeared to be less potent than doxorubicin against all doxorubicin sensitive human cancer cell lines tested. However, these compounds retained considerable cytotoxic activity against the doxorubicin-resistant cell line MCF7/ADR, implying their therapeutic potential to treat doxorubicin-resistant tumors. The most active compound 4c was equipotent with doxorubicin against HCT15 cell line.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-010-0503-z

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)