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Title 

Alkamides from Piper longum and Piper nigrum as inhibitors of IL-6 action

 

필발 및 호초로부터 분리된 알카마이드화합물의 IL-6 저해활성

Authors 

Seung Woong LeeKim myo seonPark Mi-hyeSu-Jin ParkWoo Song LeeJong Sun ChangMun Chual Rho

Publisher 

The Korean Chemical Society

Issue Date 

2010

Citation 

Bulletin of the Korean Chemical Society, vol. 31, no. 4, pp. 921-924

Keywords 

Interleukin-6Piper longumPiper nigrumStat3

Abstract 

Blocking of IL-6 has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine the potential effects of alkamides isolated from P. longum and P. nigrum on IL-6 induced Stat3 activation and identify the structure-activity relationship of these alkamides in human hepatoma cells. Among 10 alkamides isolated from P. longum and P. nigrum, compounds 6, 7 and 9 were identified as strong inhibitors of IL-6 action, which inhibit IL-6 induced Stat3-dependent luciferase activities. These inhibitory activities were positively influenced by the presence of piperidine moiety.

ISSN 

0253-2964

Link 

http://dx.doi.org/10.5012/bkcs.2010.31.04.921

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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