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Title 

Methyl-branched fatty acids, inhibitors of enoyl-ACP reductase with antibacterial activity from Streptomyces sp. A251

 

Streptomyces sp. A251이 생산하는 enoyl-ACP reductase 저해 항세균 methyl-branched fatty acid 물질

Authors 

C J ZhengMi Jin SohnSeung-Wook ChiWon Gon Kim

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2010

Citation 

Journal of Microbiology and Biotechnology, vol. 20, no. 5, pp. 875-880

Keywords 

Antibacterial activityEnoyl-ACP reductaseMethyl-branched fatty acidStaphylococcus aureus

Abstract 

Bacterial enoyl-ACP reductase (FabI) has been demonstrated to be a novel antibacterial target. In the course of our screening for FabI inhibitors, we isolated two methyl-branched fatty acids from Streptomyces sp. A251. They were identified as 14-methyl-9(Z)-pentadecenoic acid and 15-methyl-9(Z)-hexadecenoic acid by MS and NMR spectral data. These compounds inhibited Staphylococcus aureus FabI with IC50 values of 16.0 and 16.3 uM, respectively, but did not affect FabK, an enoyl-ACP reductase of Streptococcus pneumonia, at 100 uM. Consistent with their selective inhibition for FabI, they blocked intracellular fatty acid synthesis as well as the growth of S. aureus, but did not inhibit the growth of S. pneumonia. Additionally, these compounds showed reduced antibacterial activity against /abl-overexpressing S. aureus, compared with the wild-type strain. These results demonstrate that the methyl-branched fatty acids show antibacterial activity by inhibiting FabI in vivo.

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.1001.01004

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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