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Title 

Hypopigmentary action of dihydropyranocoumarin D2, a decursin derivative, as a MITF-degrading agent

Authors 

D S KimS H ParkH K LeeSoo-Jin ChooJ H LeeG Y SongIck Dong YooS B KwonJ I NaK C Park

Publisher 

American Chemical Society

Issue Date 

2010

Citation 

Journal of Natural Products, vol. 73, no. 5, pp. 797-800

Abstract 

In this study, the decursin derivative dihydropyranocoumarin D2 (1) was selected for its effects on melanogenesis using a spontaneously immortalized mouse melanocyte cell line (Mel-Ab). The results showed that 1 effectively inhibited melanin synthesis in a concentration-dependent manner, but that it did not inhibit tyrosinase in a cell-free system. In addition, the changes in ERK, Akt, and microphthalmia-associated transcription factor (MITF) in response to treatment with 1 were assessed. The results revealed that ERK was dramatically up-regulated and MITF was down-regulated in response to treatment with 1, but that Akt was unchanged. Therefore, the effects of 1 on melanogenesis were examined in the absence or presence of PD98059 (a specific inhibitor of the ERK pathway). PD98059 restored hypopigmentation and the down-regulation of MITF induced by 1. Finally, MITF down-regulation by 1 was clearly restored by both chloroquine, a lysosomal proteolysis inhibitor, and MG132, a proteasome inhibitor.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np900455j

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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