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Title 

Isolation and identification of pentagalloylglucose with the broad-spectrum of antibacterial activity from Rhus trichocarpa Miquel

 

Rhus trichocapa이 생산하는 항세균물질 pentagalloylglucose의 분리 및 동정

Authors 

J Y ChoMi Jin SohnJoongku LeeWon Gon Kim

Publisher 

Elsevier

Issue Date 

2010

Citation 

Food Chemistry, vol. 123, no. 2, pp. 501-506

Keywords 

Antibacterial activityBacteriostaticBroad-spectrumPenta-O-galloylglucoseRhus trichocarpa

Abstract 

Rhus trichocarpa Miquel has been utilised both as a food and for medicinal purposes. In this study, we determined that the methanol extracts of the stem and leaf portions of R. trichocarpa inhibited the growth of both Gram-negative and Gram-positive bacteria. The active constituent was isolated, and identified via mass spectrometry and NMR as 1,2,3,4,6-penta-O-galloyl-β-d-glucose. The compound also evidenced a broad spectrum of antibacterial activity against both Gram-negative and Gram-positive bacteria including Staphylococcus aureus (both methicillin-resistant S. aureus and quinolone-resistant S. aureus), Bacillus subtilis, Streptococcus mutans, Escherichia coli, Salmonella typhimurium, and Pseudomonas aeruginosa with MRC values of 16-32 μg/ml, whereas gallate failed to inhibit the growth of Gram-negative bacteria, even at a concentration of 128 μg/ml. The antibacterial activity of penta-O-galloylglucose was restored by the addition of Fe2+, whereas gallate was not, thereby indicating that its antibacterial activity could be attributable to the chelation of iron. The results of the time-kill study against S. aureus and E. coli revealed that penta-O-galloylglucose exhibited bacteriostatic activity. These findings indicate that the extracts of R. trichocarpa as well as its active component, penta-O-galloylglucose, may have profound potential for the control of both Gram-positive and negative pathogens.

ISSN 

0308-8146

Link 

http://dx.doi.org/10.1016/j.foodchem.2010.04.072

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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