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Title 

YC-1 enhances natural killer cell differentiation from hematopoietic stem cells

Authors 

Sohyun YunSuk Hyung LeeYun Hee KangMi-Ra JeongMi-Joung KimMi-Sun KimpiaozhenghaoHyun-Woo SuhTae-Don KimP K MyungSuk Ran YoonIn Pyo Choi

Publisher 

Elsevier

Issue Date 

2010

Citation 

International Immunopharmacology, vol. 10, no. 4, pp. 481-486

Keywords 

DifferentiationHematopoietic stem cellsNK cellsp38YC-1

Abstract 

NK cells play crucial roles in innate immunity and adaptive immunity. The detailed mechanisms, however, governing NK cell development remains unclear. In this study, we report that YC-1 significantly enhances NK cell populations differentiated from human umbilical cord blood hematopoietic stem cells (HSCs). NK cells increased by YC-1 display both phenotypic and functional features of fully mature NK (mNK) cells, but YC-1 does not affect the activation of mNK cells. YC-1 did not affect cGMP production and phosphorylation of STAT-5 which is essential for IL-15R signaling. On the other hand, YC-1 increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, p38 inhibitor SB203580 inhibited the differentiation of NK cells enhanced by YC-1. Taken together, these data suggest that YC-1 enhances NK cell differentiation through the activation of p38 MAPK which is involved in NK cell differentiation.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2010.01.009

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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