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Title 

Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry

Authors 

Jeong Ki KimG KayaliD WalkerH L ForrestA H EllebedyY S GriffinA RubrumM M BahgatM A KutkatM A A AliJ R AldridgeN J NegovetichS KraussR J WebbyR G Webster

Publisher 

National Academy of Sciences

Issue Date 

2010

Citation 

Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 24, pp. 11044-11049

Keywords 

ImmuneMaternally transferred antibodiesSuppression

Abstract 

In Egypt, efforts to control highly pathogenic H5N1 avian influenza virus in poultry and in humans have failed despite increased biosecurity, quarantine, and vaccination at poultry farms. The ongoing circulation of HP H5N1 avian influenza in Egypt has caused >100 human infections and remains an unresolved threat to veterinary and public health. Here,we describe that the failure of commercially available H5 poultry vaccines in Egyptmay be caused in part by the passive transfer of maternal H5N1 antibodies to chicks, inhibiting their immune response to vaccination. We propose that the induction of a protective immune response to H5N1 is suppressed for an extended period in young chickens. This issue, among others,must be resolved and additional steps must be taken before the outbreaks in Egypt can be controlled.

ISSN 

0027-8424

Link 

http://dx.doi.org/10.1073/pnas.1006419107

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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