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Title 

Water extract of triticum aestivum L. and its components demonstrate protective effect in a model of vascular dementia

Authors 

H S HanJ H JangJ S ChoiY J KimC LeeS H LimHyeong Kyu LeeJ Lee

Publisher 

Mary Ann Liebert

Issue Date 

2010

Citation 

Journal of Medicinal Food, vol. 13, no. 3, pp. 572-578

Keywords 

learning and memoryneuroprotectionwhite matter injury

Abstract 

Although vascular dementia is the second leading cause of dementia and often underdiagnosed, there are no drugs yet approved for the treatment of vascular dementia. In this study, it is demonstrated that water extract of Triticum aestivum L. (TALE) and some of its components have protective effects against vascular dementia-induced damage by preserving the myelin sheath and inhibiting astrocytic activation. The memory test used a vascular dementia model utilizing bilateral ligation of the carotid arteries of rats. TALE, some of its components, such as starch, total dietary fiber (TDF), arabinoxylan, β-glucan, and degraded products of arabinoxylan, such as arabinose and xylose, were administered to the animals from day 8 to day 14, following the surgery. Twenty-one days after the surgery, the water maze test was performed for 5 days, and the time taken to find the platform during training trials (mean escape latency) was measured. The mean escape latency was decreased consistently in the TALE-, starch-, TDF-, arabinoxylan-, and arabinose-treated groups, compared with that in the vascular dementia group. To measure brain damage, Luxol fast blue staining and immunohistochemistry of myelin basic protein (MBP) were performed to observe myelin sheath in the white matter, and immunohistochemistry of glial fibrillary acidic protein (GFAP) was performed to observe the astrocytic reaction. Vascular dementia reduced the MBP level and increased the GFAP level. Arabinose effectively inhibited the MBP and GFAP change, whereas arabinoxylan inhibited the GFAP change only. These results suggest that TALE and some of its components can be used as a medicinal material for the development of neuroprotective agents against vascular dementia.

ISSN 

1096-620X

Link 

http://dx.doi.org/10.1089/jmf.2009.1242

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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