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Title 

Whole human exome capture for high-throughput sequencing

Authors 

D W KimSeong-Hyeuk NamRyong Nam KimSang-Haeng ChoiHong-Seog Park

Publisher 

NRC Research Press (Canadian Science Publishing)

Issue Date 

2010

Citation 

Genome, vol. 53, no. 0, pp. 568-574

Abstract 

We captured the whole human exome by hybridization using synthesized oligonucleotides, based on a high-density microarray design, and we sequenced those captured human exons using high-throughput sequencing on a Genome Sequencer FLX instrument. of the uniquely mapped reads, 71% fell within target regions, and these corresponded to coverage of 94% of human genes, 87% of exons, and 70% of the total base-pair length of the CCDS set. Our study provides strong evidence for the practical usefulness of this method on a genome-wide scale, showing the resequenced whole human exome database with 501 microRNAs and 307 novel SNPs.

ISSN 

0831-2796

Link 

http://dx.doi.org/10.1139/G10-025

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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