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Title 

Structure-activity relationship of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives

Authors 

J W KwakY KimH ParkJ Y JangK K LeeW YiJ A KwakSong Kyu ParkHwan Mook KimKiho LeeJong Soon KangS B HanB Y HwangJ T HongJ K JungJ ChoH Lee

Publisher 

Elsevier

Issue Date 

2010

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 20, no. 15, pp. 4620-4623

Keywords 

Cytotoxic activityIndoline-2-carboxamideNF-κB inhibitors

Abstract 

Chroman derivatives exhibited potent inhibitory activity of NF-κB. For SAR, the chroman scaffold was modified with an indoline moiety. A series of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives were synthesized to explore their inhibitory activities of NF-κB and they were also evaluated for cytotoxicity against various cancer cell lines. Since intermediates with Boc showed outstanding results, various substituents in place of the Boc group were introduced additionally and these compounds were also evaluated for SAR.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2010.06.004

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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