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Title 

Inhibition of VLA-4/VCAM-1-mediated cell adhesion by triterpenoid saponins from Bupleurum falcatum L

 

시호로부터 분리된 트리터페노이드 사포닌의 VLA-4/VCAM-1에 의해 유도되는 세포접착 저해활성

Authors 

Seung Woong LeeMin Seok KimJu-Hwan LimJong Sun ChangJ LingK H BaeWoo Song LeeMun Chual Rho

Publisher 

The Korean Chemical Society

Issue Date 

2010

Citation 

Bulletin of the Korean Chemical Society, vol. 31, no. 7, pp. 1931-1936

Keywords 

Bupleurum falcatum LSaikosaponinsUmbelliferaeVascular cell adhesion molecule-1 (VCAM-1)Very late antigen-4 (VLA-4)

Abstract 

Discovery and isolation of compounds capable of blocking the interactions between VCAM-1 and VLA-4, a major pair of adhesion molecules contributing to the different steps of leukocyte migration across the endothelium in inflammatory responses, has been a major goal of this lab. Through bioactivity-guided fractionation, five saikosaponins were subsequently isolated from the methanol extracts of the roots of Bupleurum falcatum L. Their structures were elucidated by spectroscopic analysis (1H-, 13C-NMR and 2D-NMR), as follows, saikosaponins: A (1); D (2); C (3); B3 (4); B4 (5). Compounds 1 and 2 inhibited interaction of sVCAM-1 and VLA-4 of THP-1 cells with respective IC50 values of 7.8 and 1.7 μM. The aglycone structure of 2 also showed cell adhesion inhibitory activity with an IC50 value of 21.1 μM. With these results, we suspect these two saikosaponins from the Bupleurum falcatum L. roots to be prime candidates for therapeutic strategies towards inflammation.

ISSN 

0253-2964

Link 

http://dx.doi.org/10.5012/bkcs.2010.31.7.1931

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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