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Title 

Production of recombinant human granulocyte macrophage colony-stimulating factor from silkworm Bombyx mori Bm5 cells

Authors 

C Y JinS Y HanK KwonE Y YunS W KangT W GooS W KimKweon YuO Y Kwon

Publisher 

Verlag der Zeitschrift Fuer Naturforschung

Issue Date 

2010

Citation 

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences, vol. 65, no. 1, pp. 153-156

Keywords 

Human granulocyte macrophage colony-stimulating factorSilkworm bombyx mori bm5 cellsWhite blood cell

Abstract 

Using silkworm Bombyx mori Bm5 cells, we established a stable cell line expressing the human granulocyte macrophage colony-stimulating factor (hGM-CSF), which gets its name from the Bm5-hGM-CSF cell in which the glycoprotein of the hGM-CSF is secreted in the cell culture supernatant (CCS). It was demonstrated that secreted hGM-CSF had in vivo biological activity and the white blood cell (WBC) value increased two times that of the control. We expect to produce useful human recombinant glycoproteins from silkworm cultured cells for a low price and a large quantity.

ISSN 

0939-5075

Link 

http://dx.doi.org/https://doi.org/10.1515/znc-2010-1-224

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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