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Title 

Hydroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus

Authors 

In Ja RyooB S YunI K LeeY H KimIck Soo LeeJong Seog AhnK BaeIck Dong Yoo

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2010

Citation 

Journal of Microbiology and Biotechnology, vol. 20, no. 8, pp. 1189-1191

Keywords 

Hibiscus syriacusHuman neutrophil elastaseHydroxyhibiscone A

Abstract 

In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to posses significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 μM, respectively.

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.1004.04028

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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