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Title 

Feasibility of FAIR imaging for evaluating tumor perfusion

Authors 

J H ChoG ChoY SongC LeeB W ParkC K LeeN KimS B ParkJong Soon KangM R KangHwan Mook KimY R KimK S ChoJ K Kim

Publisher 

Wiley-Blackwell

Issue Date 

2010

Citation 

Journal of Magnetic Resonance Imaging, vol. 32, no. 3, pp. 738-744

Keywords 

AngiogenesisArterial spin labelingBlood flowFlow-sensitive alternating inversion recoveryMagnetic resonance imaging

Abstract 

Purpose: To evaluate the feasibility of flow-sensitive alternating inversion recovery (FAIR) for measuring blood flow in tumor models. Materials and Methods: In eight mice tumor models, FAIR and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was performed. The reliability for measuring blood flow on FAIR was evaluated using the coefficient of variation of blood flow on psoas muscle. Three regions of interest (ROIs) were drawn in the peripheral, intermediate, and central portions within each tumor. The location of ROI was the same on FAIR and DCE-MR images. The correlation between the blood flow on FAIR and perfusion-related parameters on DCE-MRI was evaluated using the Pearson correlation coefficient. Results: The coefficient of variation for measuring blood flow was 9.8%. Blood flow on FAIR showed a strong correlation with Kep (r = 0.77), percent relative enhancement (r = 0.73), and percent enhancement ratio (r = 0.81). The mean values of blood flow (mL/100 g/min) (358 vs. 207), Kep (sec-1) (7.46 vs. 1.31), percent relative enhancement (179% vs. 134%), and percent enhancement ratio (42% vs. 26%) were greater in the peripheral portion than in the central portion (P < 0.01). Conclusion: As blood flow measurement on FAIR is reliable and closely related with that on DCE-MR, FAIR is feasible for measuring tumor blood flow.

ISSN 

1053-1807

Link 

http://dx.doi.org/10.1002/jmri.22298

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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