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Title 

In vitro chemosensitivity of gastric adenocarcinomas to histone deacetylase inhibitors, compared to established drugs

Authors 

S N YoonS A RohD H ChoM B KimY L HyunS RoB S KimSeon-Young KimYong Sung KimJ C Kim

Publisher 

Hge Update Medical Publishing Sa

Issue Date 

2010

Citation 

Hepato-Gastroenterology, vol. 57, no. 99, pp. 657-662

Keywords 

ChemosensitivityGastric adenocarcinomasHistoculture drug response assay (HDRA)Histone deacetylase inhibitor

Abstract 

BACKGROUND/AIMS: This study was performed to determine the efficacy of histone deacetylase inhibitors in gastric cancer, together with other established regimens. METHODOLOGY: The chemosensitivities of 93 gastric cancer patients to established drugs, and three histone deacetylase inhibitors (SAHA, PXD101, and a novel candidate, CG-2) were evaluated using the histoculture drug response assay. RESULTS: Tumor growth inhibition rates were the highest with cisplatin, followed by PXD101, taxol, docetaxel, and TS-1, in descending order. The response rates were 41.9-68.8%, and 37.6-47.3%, respectively, at an inhibition rate cutoff value of 30%. Synergistic activity was evident with most combinations of established drugs and histone deacetylase inhibitors. Diffuse- or mixed-type carcinomas on Lauren classification were closely associated with increased chemosensitivity to TS-1 (p = 0.044). Node-positive and "other than tubular type" tumors on WHO classification were chemosensitive to cisplatin (p = 0.011 and 0.014, respectively). CG-2 chemosensitivity was markedly associated with low preoperative CA72-4 level (≤4 U/ml) (p = 0.046). CONCLUSIONS: This in vitro chemosensitivity assay validates the comparable chemo-response of gastric cancers to histone deacetylase inhibitors and established drugs, indicating considerable therapeutic efficacy of these agents. Additionally, a number of clinicopathological parameters are significantly associated with specific regimens.

ISSN 

0172-6390

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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