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Title 

Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ

Authors 

D W KimK B KimJ Y KimKyu-Sun LeeS B Seo

Publisher 

Elsevier

Issue Date 

2010

Citation 

Biochemical and Biophysical Research Communications, vol. 400, no. 3, pp. 419-425

Keywords 

INHATNeuronal differentiationRetinoic acidSET/TAF-Iβ

Abstract 

Epigenetic modification plays an important role in transcriptional regulation. As a subunit of the INHAT (inhibitor of histone acetyltransferases) complex, SET/TAF-Iβ evidences transcriptional repression activity. In this study, we demonstrate that SET/TAF-Iβ is abundantly expressed in neuronal tissues of Drosophila embryos. It is expressed at high levels prior to and in early stages of neuronal development, and gradually reduced as differentiation proceeds. SET/TAF-Iβ binds to the promoters of a subset of neuronal development markers and negatively regulates the transcription of these genes. The results of this study show that the knockdown of SET/TAF-Iβ by si-RNA induces neuronal cell differentiation, thus implicating SET/TAF-Iβ as a negative regulator of neuronal development.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2010.08.093

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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