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Title 

Kansuinine A and Kansuinine B from Euphorbia kansui L. Inhibit IL-6-induced Stat3 Activation

 

감수로부터 분리한 칸수이닌 A와 B의 IL-6유도 STAT3활성저해

Authors 

Jong Sun ChangSeung Woong LeeMi-Hye ParkM S KimB I HudsonSu-Jin ParkWoo Song LeeMun Chual Rho

Publisher 

Georg Thieme Verlag

Issue Date 

2010

Citation 

Planta Medica, vol. 76, no. 14, pp. 1544-1549

Keywords 

ERK1/2Euphorbia kansui LiouEuphorbiaceaeIL6kansuinine Akansuinine BStat3

Abstract 

The current study was performed to examine the mechanisms underlying the potential effects of E. kansui on IL-6-induced cellular signaling in human hepatoma cells. We found that two diterpenoids, kansuinine A and B, from E. kansui have an inhibitory effect on IL-6-induced Stat3 activation by activating ERK1/2. Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. These results suggest that blocking of IL-6-induced signal transduction is partially due to the sustained activation of ERK1/2 by kansuinine A and B, which in turn results in an increase of Stat3 serine phosphorylation and SOCS-3 expression. Treatment with kansuinine A and B represents a novel method to block these IL-6-induced effects.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-0030-1249805

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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