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Title 

Inhibition of bone marrow-derived dendritic cell maturation by glabridin

Authors 

J Y KimJong Soon KangHwan Mook KimH S RyuH S KimH K LeeY J KimJ T HongY KimS B Han

Publisher 

Elsevier

Issue Date 

2010

Citation 

International Immunopharmacology, vol. 10, no. 10, pp. 1185-1193

Keywords 

Dendritic cellsGlabridinMAPKsMaturationNF-ΚB

Abstract 

Glabridin has multiple pharmacological activities including anti-microbial, anti-atherosclerotic, anti-nephritic, anti-inflammatory and cardiovascular protective activities. In this study, we investigated the effect of glabridin on dendritic cells, which play an essential role in innate and adaptive immune responses. Glabridin inhibited lipopolysaccharide-, poly (I:C)-, or zymosan-induced phenotypic maturation of dendritic cells (DCs), as proven by the decreased expression of CD40, CD80, CD86, MHC-I, and MHC-II. Glabridin decreased the functional maturation of DCs, in that glabridin attenuated pro-inflammatory cytokine production of IL-12, IL-1β, TNF-β, and IFN-α/β, enhanced antigen capture capacity, inhibited migration to SDF-1Κ and MIP-3β, and impaired induction of allogenic T cell activation. We also showed that glabridin inhibited zymosan-induced inflammation in mice. As a mode of action, we showed that glabridin inhibited degradation of IΚBα/β, nuclear translocation of NF-ΚB p65/p50, and phosphorylation of ERK, JNK, and p38 MAPKs. Taken together, the present results show that glabridin inhibits dendritic cell maturation by blocking NF-ΚB and MAPK signalings.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2010.06.025

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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