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Title 

Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-κB pathway

Authors 

H R JinX JinJung Joon Lee

Publisher 

Elsevier

Issue Date 

2010

Citation 

Biochemical and Biophysical Research Communications, vol. 400, no. 4, pp. 581-586

Keywords 

LIGHTLTβRNF-κBNIKP52ZFP91

Abstract 

LIGHT is a member of tumor necrosis factor (TNF) superfamily, and its function is mediated through lymphotoxin-β receptor (LTβR), which is known to play important roles in inflammatory and immune responses through activation of NF-κB signaling pathways. However, molecular mechanism of LTβR ligation-induced NF-κB signaling remains incompletely understood. In this report we demonstrate that a novel zinc-finger protein 91 (ZFP91) is a critical regulator in LIGHT-induced activation of non-canonical NF-κB pathway. ZFP91 appears to be required for NF-κB2 (p100) processing to p52, nuclear translocation of p52 and RelB, and DNA-binding activity of NF-κB in LIGHT-induced activation of non-canonical NF-κB pathway. Furthermore, ZFP91 knock-down by RNA interference blocks the LIGHT-induced accumulation of NIK and p100 processing, as well as the expression of non-canonical NF-κB target genes. These data clearly indicate that ZFP91 is a key regulator in LIGHT-induced activation of non-canonical NF-κB pathway in LTβR signaling.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2010.08.107

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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