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Title | Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-κB pathway |
Authors | H R Jin; X Jin; Jung Joon Lee |
Publisher | Elsevier |
Issue Date | 2010 |
Citation | Biochemical and Biophysical Research Communications, vol. 400, no. 4, pp. 581-586 |
Keywords | LIGHT; LTβR; NF-κB; NIK; P52; ZFP91 |
Abstract | LIGHT is a member of tumor necrosis factor (TNF) superfamily, and its function is mediated through lymphotoxin-β receptor (LTβR), which is known to play important roles in inflammatory and immune responses through activation of NF-κB signaling pathways. However, molecular mechanism of LTβR ligation-induced NF-κB signaling remains incompletely understood. In this report we demonstrate that a novel zinc-finger protein 91 (ZFP91) is a critical regulator in LIGHT-induced activation of non-canonical NF-κB pathway. ZFP91 appears to be required for NF-κB2 (p100) processing to p52, nuclear translocation of p52 and RelB, and DNA-binding activity of NF-κB in LIGHT-induced activation of non-canonical NF-κB pathway. Furthermore, ZFP91 knock-down by RNA interference blocks the LIGHT-induced accumulation of NIK and p100 processing, as well as the expression of non-canonical NF-κB target genes. These data clearly indicate that ZFP91 is a key regulator in LIGHT-induced activation of non-canonical NF-κB pathway in LTβR signaling. |
ISSN | 0006-291X |
Link | |
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Registered Date |
2019-05-02 |
