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Title 

Transmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasis

Authors 

S A LeeT Y KimT K KwakH KimSemi KimH J LeeS H KimK H ParkH J KimM ChoJ W Lee

Publisher 

Wiley-Blackwell

Issue Date 

2010

Citation 

Journal of Cellular Biochemistry, vol. 111, no. 1, pp. 59-66

Keywords 

InvadopodiaInvasionMetastasisMigrationMMPTM4SF5

Abstract 

Overexpression of transmembrane 4 L six family member 5 (TM4SF5), a four-transmembrane L6 family member, causes aberrant cell proliferation and angiogenesis, but the roles of TM4SF5 in migration, invasion, and tumor metastasis remain unknown. Using in vitro hepatocarcinoma cells that ectopically or endogenously express TM4SF5 and in vivo mouse systems, roles of TM4SF5 in metastatic potentials were examined. We found that TM4SF5 expression facilitated migration, invadopodia formation, MMP activation, invasion, and eventually lung metastasis in nude mice, but suppression of TM4SF5 with its shRNA blocked the effects. Altogether, TM4SF5-mediated migration and invasion suggest that TM4SF5 may be therapeutically targeted to deal with TM4SF5-mediated hepatocellular cancers.

ISSN 

0730-2312

Link 

http://dx.doi.org/10.1002/jcb.22662

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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