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Title 

In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis

 

감초로부터 항로타바이러스활성을 지니는 폴리페놀화합물의 개발

Authors 

Hyung Jun KwonHa-Hyeon KimYoung Bae RyuJang Hoon KimHyung Jae JungSeung Woong LeeJong Sun ChangK O ChoMun Chual RhoSu-Jin ParkWoo Song Lee

Publisher 

Elsevier

Issue Date 

2010

Citation 

Bioorganic & Medicinal Chemistry, vol. 18, no. 21, pp. 7668-7674

Keywords 

Anti-rotavirusGlycyrrhiza uralensisHemagglutininViral absorptionViral replication

Abstract 

We evaluated the ability of six polyphenols isolated from the roots of Glycyrrhiza uralensis to inactivate rotaviruses, specially G5P[7] and G8P[7]. Upon finding that all polyphenols possessed anti-rotavirus activity, we evaluated whether these properties were attributable to direct inhibition of the binding of rotavirus to cells and/or to inhibition of viral replication. Using the virucidal assay, we found that all six compounds directly inhibited rotavirus binding, with activity being dependent on the type of virus. The 50% effective inhibitory concentrations (EC50) of the six compounds were 18.7-69.5 μM against G5P[7] and 14.7-88.1 μM against G8P[7], respectively. Five of the six compounds inhibited hemagglutination activity. Moreover, the CPE inhibition assay showed that five compounds inhibited viral replication with EC50 values of 12.1-24.0 μM against G5P[7] and 12.0-42.0 μM against G8P[7], respectively. RT-PCR showed that the compounds suppressed viral RNA synthesis in TF-104 cells. Interestingly, the anti-rotavirus activities of four compounds were attributable to inhibition of both viral absorption and viral replication. These results suggest that compounds isolated from the roots of G. uralensis may be potent anti-rotavirus agents in vivo, acting by inhibiting both viral absorption and viral replication.

ISSN 

0968-0896

Link 

http://dx.doi.org/10.1016/j.bmc.2010.07.073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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