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Title 

Vitamin D3 upregulated protein 1 suppresses TNF-α-induced NF-κB activation in hepatocarcinogenesis

 

VDUP1에 의한 TNF유도 NF-kB 활성의 저해

Authors 

Hyo Jung KwonYoung Suk WonHyun-Woo SuhJ H JeonY ShaoSuk Ran YoonJ W ChungTae-Don KimHwan Mook KimKi Hoan NamWoon Kee YoonD G KimJ H KimYong Sung KimD Y KimHyoung-Chin KimIn Pyo Choi

Publisher 

American Association of Immunologists

Issue Date 

2010

Citation 

Journal of Immunology, vol. 185, no. 7, pp. 3980-3989

Abstract 

Vitamin D(3) upregulated protein 1 (VDUP1) is a candidate tumor suppressor, the expression of which is dramatically reduced in various tumor tissues. In this study, we found that VDUP1 expression is suppressed during human hepatic carcinogenesis, and mice lacking VDUP1 are much more susceptible to diethylnitrosamine-induced hepatocarcinogenesis compared with wild type mice. VDUP1-deficient tumors proliferated significantly more than wild type tumors and had corresponding changes in the expression of key cell cycle regulatory proteins. In addition, the hepatomitogen-induced response was associated with a considerable increase in the release of TNF-α and subsequent enhancement of NF-κB activation in VDUP1-deficient mice. When cells were treated with TNF-α, the VDUP1 level was markedly reduced, concomitant with elevated NF-κB activation. Furthermore, the overexpression of VDUP1 resulted in the robust suppression of TNF-α-activated NF-κB activity via association with HDAC1 and HDAC3. These results indicate that VDUP1 negatively regulates hepatocarcinogenesis by suppressing TNF-α-induced NF-κB activation.

ISSN 

0022-1767

Link 

http://dx.doi.org/10.4049/jimmunol.1000990

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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