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Title 

Polyphenols displaying tyrosinase inhibition from the seed of Psoralea corylifolia

Authors 

J Y KimK Y OhH W RyuTae Sook JeongK H Park

Publisher 

Korean Society for Applied Biological Chemisty

Issue Date 

2010

Citation 

Journal of Korean Society for Applied Biological Chemistry, vol. 53, no. 4, pp. 427-432

Keywords 

MonophenolaseMushroom tyrosinasePrenylated chalconePsoralea corylifoliaReferences

Abstract 

Three chalcones and two flavanones displaying tyrosinase inhibitory activity were isolated from the seed of Psoralea corylifolia, a cultivated edible plant. The isolated compounds were elucidated as known isovabachalcone, 4'-O-methylbavachalcone, isobavachromene, corylifolin, and bavachinin. The inhibitory potencies of the polyphenols toward monophenolase activity of mushroom tyrosinase were investigated. The inhibitory concentration (IC50) values of compounds 1-5 for monophenolase activity were determined to be 12.3, 48.8, 15.8, 23.6, and 143.9 μM, respectively. The potent inhibitors 1-4 exhibited the competitive inhibition characteristics in analysis of Lineweaver-Burks and Dixon-plot.

ISSN 

1738-2203

Link 

http://dx.doi.org/10.3839/jksabc.2010.066

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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