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Title | Polyphenols displaying tyrosinase inhibition from the seed of Psoralea corylifolia |
Authors | J Y Kim; K Y Oh; H W Ryu; Tae Sook Jeong; K H Park |
Publisher | Korean Society for Applied Biological Chemisty |
Issue Date | 2010 |
Citation | Journal of Korean Society for Applied Biological Chemistry, vol. 53, no. 4, pp. 427-432 |
Keywords | Monophenolase; Mushroom tyrosinase; Prenylated chalcone; Psoralea corylifolia; References |
Abstract | Three chalcones and two flavanones displaying tyrosinase inhibitory activity were isolated from the seed of Psoralea corylifolia, a cultivated edible plant. The isolated compounds were elucidated as known isovabachalcone, 4'-O-methylbavachalcone, isobavachromene, corylifolin, and bavachinin. The inhibitory potencies of the polyphenols toward monophenolase activity of mushroom tyrosinase were investigated. The inhibitory concentration (IC50) values of compounds 1-5 for monophenolase activity were determined to be 12.3, 48.8, 15.8, 23.6, and 143.9 μM, respectively. The potent inhibitors 1-4 exhibited the competitive inhibition characteristics in analysis of Lineweaver-Burks and Dixon-plot. |
ISSN | 1738-2203 |
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Appears in Collections | |
Registered Date |
2017-04-19 |
