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Title 

Expression of hepatitis B virus X protein in hepatocytes suppresses CD8+ T cell activity

Authors 

M J LeeY H JinK KimY ChoiHyoung-Chin KimS Park

Issue Date 

2010

Citation 

Immune Network, vol. 10, no. 4, pp. 126-134

Abstract 

BACKGROUND: CD8(+) T cells contribute to the clearance of Hepatitis B virus (HBV) infection and an insufficient CD8(+) T cell response may be one of the major factors leading to chronic HBV infection. Since the HBx antigen of HBV can up-regulate cellular expression of several immunomodulatory molecules, we hypothesized that HBx expression in hepatocytes might affect CD8(+) T cell activity. METHODS: We analyzed the activation and apoptosis of CD8(+) T cells co-cultured with primary hepatocytes rendered capable of expressing HBx by recombinant baculovirus infection. RESULTS: Expression of HBx in hepatocytes induced low production of interferon-γ and apoptosis of CD8(+) T cells, with no effect on CD8 T cell proliferation. However, transcriptional levels of H-2K, ICAM-1 and PD-1 ligand did not correlate with HBx expression in hepatocytes. CONCLUSION: Our results suggest that HBx may inhibit CD8(+) T cell response by regulation of interferon-γ production and apoptosis.

ISSN 

1598-2629

Link 

http://dx.doi.org/10.4110/in.2010.10.4.126

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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