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Title 

Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors

Authors 

H SongSei Ryang OhHyeong Kyu LeeG HanJ H KimH W ChangK E DohH K RheeH Y Park Choo

Publisher 

Elsevier

Issue Date 

2010

Citation 

Bioorganic & Medicinal Chemistry, vol. 18, no. 21, pp. 7580-7585

Keywords 

5-LOX inhibitorsAirway hypersensitivenessBenzoxazoles

Abstract 

5-Lipoxygenase (5-LOX) is important enzyme in the biosynthesis of leukotrienes, and is a potential target in the treatment of asthma and allergy. We designed and synthesized a series of benzoxazoles and benzothiazoles as 5-LOX inhibitors. Fourteen compounds prepared showed the inhibition of LTC4 formation with IC50 value of 0.12-23.88 μM. Also two compounds 2d and 2g showed improved airway hypersensitiveness.

ISSN 

0968-0896

Link 

http://dx.doi.org/10.1016/j.bmc.2010.08.047

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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