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Title 

Fabrication of a structure-specific RNA binder for array detection of label-free microRNA

 

신규 RNA 결합단백질의 개발을 통한 마이크로 RNA 어레이 분석

Authors 

Jeong Min LeeHyeon Min JoYongwon Jung

Publisher 

Wiley-Blackwell

Issue Date 

2010

Citation 

Angewandte Chemie International Edition, vol. 49, no. 46, pp. 8662-8665

Keywords 

biosensorsmicroarraysmicroRNAprotein designRNA recognition

Abstract 

Like an antibody: A novel structure-specific RNA-binding protein was designed to stably and specifically bind to surface-bound microRNAs. By acting like an antibody, this RNA binder enabled the universal detection of hybridized microRNAs on array surfaces (see picture) without any enzymatic amplification or labeling reactions. ? 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

ISSN 

1433-7851

Link 

http://dx.doi.org/10.1002/anie.201004000

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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