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Title 

Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells

Authors 

K LeeJ H LeeS K BoovanahalliY ChoiSoo-Jin ChooIck Dong YooD H KimM Y YunG W LeeG Y Song

Publisher 

Elsevier

Issue Date 

2010

Citation 

European Journal of Medicinal Chemistry, vol. 45, no. 12, pp. 5567-5575

Keywords 

(+)-Decursin(+)-Decursinol(+)-Decursinol angelateMelanin inhibitors

Abstract 

We report the synthesis of a novel series of highly potent melanin inhibitors which were obtained through structural modification of an anticancer compound S-(+)-decursinol. The in vitro inhibitory potencies of the newly synthesized compounds were evaluated against α-MSH induced melanin production in B16 murine melanoma cells. Among the compounds evaluated, compounds 2, 3, 6b, 7a, 7b, 8a and 8b emerged as highly potent inhibitors of melanin production. Besides, these compounds demonstrated significantly low cytotoxicity

ISSN 

0223-5234

Link 

http://dx.doi.org/10.1016/j.ejmech.2010.09.006

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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