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Title 

Inhibitory activities of Anthraquinones from Rubia akane on phosphatase regenerating liver-3

 

안스라큐논의 PRL-3 저해효과

Authors 

M K MoonYoung Min HanYu Jin LeeL H LeeJ H YangByoung-Mog KwonD K Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2010

Citation 

Archives of Pharmacal Research, vol. 33, no. 11, pp. 1747-1751

Abstract 

The methanolic extract of the roots of Rubia akane (Rubiaceae) was found to show inhibitory activity on phosphatase of regenerating liver-3 (PRL-3). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone compounds, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-α-rhamnosyl(1→2)-β-glucoside and 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone, as inhibitors on PRL-3. These compounds inhibited PRL-3 in a dose-dependent manner with IC?? values of 5.2 and 1.3 μg/mL, respectively.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-010-1106-4

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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