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Title 

Oxidative stress and antioxidants in hepatic pathogenesis

Authors 

H L HaHye Jun ShinM A FeitelsonDae Yeul Yu

Publisher 

Baishideng Publishing Group Co. Limited

Issue Date 

2010

Citation 

World Journal of Gastroenterology, vol. 16, no. 48, pp. 6035-6043

Keywords 

AlcoholAntioxidantChronic liver diseaseHepatitis B virusHepatitis B virus X proteinOxidative stress

Abstract 

Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic liver diseases, including hepatocellular carcinoma (HCC). The HBV encoded proteins, hepatitis B virus X protein and preS, appear to contribute importantly to the pathogenesis of HCC. Both are associated with oxidative stress, which can damage cellular molecules like lipids, proteins, and DNA during chronic infection. Chronic alcohol use is another important factor that contributes to oxidative stress in the liver. Previous studies reported that treatment with antioxidants, such as curcumin, silymarin, green tea, and vitamins C and E, can protect DNA from damage and regulate liver pathogenesis-related cascades by reducing reactive oxygen species. This review summarizes some of the relationships between oxidative stress and liver pathogenesis, focusing upon HBV and alcohol, and suggests antioxidant therapeutic approaches. ? 2010 Baishideng.

ISSN 

1007-9327

Link 

http://dx.doi.org/10.3748/wjg.v16.i48.6035

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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