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Title 

Suppression of proinflammatory cytokine production by specific metabolites of Lactobacillus plantarum 10hk2 via inhibiting NF-κB and p38 MAPK expressions

Authors 

H ChonB ChoiG JeongEun Gyo LeeS Lee

Publisher 

Elsevier

Issue Date 

2010

Citation 

Comparative Immunology Microbiology and Infectious Diseases, vol. 33, no. 6, pp. e41-e49

Keywords 

Anti-inflammationIL-10Lactic acid bacteriaNF-κBP38 MAPKRAW 264.7 cells

Abstract 

The objective of this study was to evaluate the immunomodulatory effects of specific bacterial metabolites of Lactobacillus plantarum 10hk2 to induce anti-inflammatory mediators in cell cultures of the murine macrophage cell line, RAW 264.7. The effects of the extracellular metabolites of this bacterial strain were examined by dividing them into protein and polysaccharide fractions. A specific protein fraction (8.7. kDa) was found to be a strong IL-10 inducer in LPS-stimulated RAW 264.7 cells and suppressed LPS-induced NF-κB induction and inhibited LPS-induced phosphorylation of I-κB and p38 MAPK. To the best of our knowledge, this was the first study that investigated the anti-inflammatory effects of an extracellular peptide derived from lactic acid bacteria. In addition, we characterized the inhibitory mode of this molecule in the induction of proinflammatory cytokines. Based on the findings presented in this study, this molecule holds promise for use as an agent to modulate inflammation related diseases. ? 2009 Elsevier Ltd.

ISSN 

0147-9571

Link 

http://dx.doi.org/10.1016/j.cimid.2009.11.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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