상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Epigenetic modification of retinoic acid-treated human embryonic stem cells

Authors 

H S CheongH C LeeB L ParkH KimM J JangY M HanSeon-Young KimYong Sung KimH D Shin

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2010

Citation 

BMB Reports, vol. 43, no. 12, pp. 830-835

Keywords 

DNA methylationEpigenetic modificationGene expressionHuman embryonic stem cellRetinoic acid

Abstract 

Epigenetic modification of the genome through DNA methylation is the key to maintaining the differentiated state of human embryonic stem cells (hESCs), and it must be reset during differentiation by retinoic acid (RA) treatment. A genome-wide methylation/gene expression assay was performed in order to identify epigenetic modifications of RA-treated hESCs. Between undifferentiated and RA-treated hESCs, 166 differentially methylated CpG sites and 2,013 differentially expressed genes were discovered. Combined analysis of methylation and expression data revealed that 19 genes (STAP2, VAMP8, C10orf26, WFIKKN1, ELF3, C1QTNF6, C10orf10, MRGPRF, ARSE, LSAMP, CENTD3, LDB2, POU5F1, GSPT2, THY1, ZNF574, MSX1, SCMH1, and RARB) were highly correlated with each other. The results provided in this study will facilitate future investigations into the interplay between DNA methylation and gene expression through further functional and biological studies.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2010.43.12.824

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)