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Title 

2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway

 

하드록시 커큐미노이드에 의한 암세포 사멸 기전 규명

Authors 

Young Min HanDae Seop ShinY J LeeS A IsmailS H HongDong Cho HanByoung-Mog Kwon

Publisher 

Elsevier

Issue Date 

2011

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 2, pp. 747-751

Keywords 

ApoptosisCurcuminoidHydroxycinnamaldehydeReactive oxygen species

Abstract 

2-Hydroxycinnamaldehyde (HCA) and curcumin have been reported to have antitumor effects against various human tumor cells in vitro and in vivo by generation of ROS. Aldehyde-free HCA analogs were synthesized based on the structure of curcumin, which we have called 2-hydroxycurcuminoids. The hydroxyl group of curcuminoids enhances the ability to generate ROS. 2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI50 value of 7 μM, while the parent compounds, HCA and curcumin, displayed GI50 values of 12 and 30 μM, respectively. HCC-7 was found to induce apoptosis through the reactive oxygen species-mitochondria pathway and cell cycle arrest at G2/M phase.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2010.11.114

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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