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Title | 2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway |
| 하드록시 커큐미노이드에 의한 암세포 사멸 기전 규명 |
Authors | Young Min Han; Dae Seop Shin; Y J Lee; S A Ismail; S H Hong; Dong Cho Han; Byoung-Mog Kwon |
Publisher | Elsevier |
Issue Date | 2011 |
Citation | Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 2, pp. 747-751 |
Keywords | Apoptosis; Curcuminoid; Hydroxycinnamaldehyde; Reactive oxygen species |
Abstract | 2-Hydroxycinnamaldehyde (HCA) and curcumin have been reported to have antitumor effects against various human tumor cells in vitro and in vivo by generation of ROS. Aldehyde-free HCA analogs were synthesized based on the structure of curcumin, which we have called 2-hydroxycurcuminoids. The hydroxyl group of curcuminoids enhances the ability to generate ROS. 2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI50 value of 7 μM, while the parent compounds, HCA and curcumin, displayed GI50 values of 12 and 30 μM, respectively. HCC-7 was found to induce apoptosis through the reactive oxygen species-mitochondria pathway and cell cycle arrest at G2/M phase. |
ISSN | 0960-894X |
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Registered Date |
2017-04-19 |
